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is intrinsically drug resistant, employing various drug resistance mechanisms such as drug resistance genes, efflux pumps and an impermeable cell wall (Nessar et al.

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117 g/mL together with azithromycin for improved activity to be noticed. On the other hand, this was however minimized as compared to the focus of manuka honey on your own, which was 0.476 g/mL. Importantly, the addition of manuka honey reduced the focus of azithromycin essential for development inhibition, regardless of subspecies. Quite possibly the most improved reduction of azithromycin concentration was noticed for M. abscessus

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pulmonary bacterial infections is azithromycin, and even though it is administered intravenously, it has approval for use in a nebulised type, which even further expands the opportunity of this combination, as therapeutic manuka honey use is looked upon as limited to topical shipping and delivery.

Minimum inhibitory concentrations of manuka honey and azithromycin both by itself and together from M. abscessus

along with the minimal bactericidal concentration (MBC) was firm as being the minimum amount concentration where by no expansion of M. abscessus

Up to now, experiments have not documented any side effects of nebulized honey, While the side effects of amikacin are significant. Thus, reducing the amikacin dosage applying manuka honey, in all likelihood, would reduce these Unintended effects, resulting in superior patient outcomes. In this way, inhaled/nebulized honey can be a promising therapy choice for M. abscessus

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